If you’ve started semaglutide or tirzepatide and suddenly feel bloated, backed up, or gassy—you’re not alone.
GLP-1 medications slow digestion as part of how they work. This helps you feel full longer and reduce calorie intake… but it can also lead to some uncomfortable GI side effects—especially in the first few weeks.
Here’s what’s going on, why it happens, and how to get relief without stopping your treatment.
GLP-1 medications mimic a hormone that slows gastric emptying—meaning food stays in your stomach longer. This helps reduce hunger and improve blood sugar control, but also slows down your entire digestive system.
Common early side effects include:
These are usually temporary and can be managed with small adjustments.
You don’t have to just tough it out. Try these patient-friendly strategies:
Aim for at least 64–80 oz of water per day. Add electrolytes or warm lemon water in the morning to kick-start digestion.
Soluble fiber like chia seeds, psyllium husk, or avocado can help keep things moving. Start slowly to avoid worsening bloating.
Even light walking or yoga can stimulate the gut and promote regularity.
Many patients find that daily magnesium can ease constipation and support muscle relaxation. Always consult your provider first.
Beans, broccoli, artificial sweeteners, and carbonated drinks can add to bloating. Keep track of your personal triggers.
Your stomach empties more slowly now. Eating too quickly can trap air and worsen fullness or pressure.it changes.
If constipation lasts more than 3–4 days, or bloating is severe and painful, reach out to your prescriber. They may:
You should never skip doses or stop your GLP-1 medication without speaking to a medical professional.
Loose skin after GLP-1 weight loss doesn’t mean you failed—it means your body has changed Digestive changes are one of the most common—but manageable—parts of starting a GLP-1. With hydration, light movement, and small tweaks to your routine, you can reduce discomfort and stay on track with your goals.
The good news? These symptoms typically ease up over time—especially as your body adjusts to your dose.
Want to find a provider that helps guide you through side effects, not just prescriptions? Click here to compare trusted telehealth providers.
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