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How to Support Muscle While Losing Fat on GLP-1s

GLP-1s help you lose fat—but without the right strategy, you could lose muscle too. Learn how to protect and build lean muscle while on semaglutide or tirzepatide using targeted protein intake, strength training, and simple daily habits.

1. Prioritize Protein

Your body needs more protein than usual during rapid fat loss. Aim for:

  • 0.7–1g of protein per pound of goal body weight
  • Spread intake across 3–5 small meals/snacks

High-protein GLP-1-friendly options:
Greek yogurt, cottage cheese, protein shakes, tofu, chicken, eggs, edamame

2. Lift Weights (or Use Resistance Bands)

Cardio is great—but strength training is essential for recomposition.

Start with:

  • 2–3 sessions per week
  • Focus on compound movements (squats, lunges, push-ups, rows)
  • Gradually increase resistance or reps

3. Stay Active on Off Days

NEAT (non-exercise activity thermogenesis) helps with fat burning. Walk, stretch, do housework—movement matters even when you’re not at the gym.

4. Monitor Your Progress Differently

The scale may stall or even rise slightly as you gain muscle and lose fat. Use:

  • Strength benchmarks (how many push-ups can you do now?)
  • Progress photos
  • Body measurements

Common Recomp Mistakes on GLP-1s

  • Skipping protein because you’re not hungry
  • Doing only cardio and avoiding strength work
  • Focusing solely on the scale
  • Stopping GLP-1s too soon, before stabilizing habits

Final Thoughts

Yes—you can lose fat and gain muscle while on a GLP-1, but it won’t happen by accident. With the right nutrition, training, and consistency, you can achieve a leaner, stronger body—not just a smaller one.

Looking for a provider who supports exercise and nutrition with GLP-1 treatment? Click here to compare top providers.

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Save time and money finding the best GLP-1 provider for you. Our search tool lets you compare providers using criteria tailored to fit your needs.

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Information on this site is for reference only and doesn't replace professional medical advice. For health-related inquiries, consult your doctor.

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