Tirzepatide and semaglutide are two of the most powerful GLP-1 medications available today—but which one is best for your weight loss goals? In this guide, we break down how they compare in effectiveness, side effects, cost, and availability to help you make the right choice.
GLP-1 medications are transforming weight loss and metabolic health. Two names dominate the conversation: semaglutide (sold under Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound). Both are powerful—but they’re not identical.
Here’s a head-to-head comparison to help you decide which might be right for your body, goals, and lifestyle.
Clinical trials have shown that tirzepatide often results in greater weight loss compared to semaglutide, with some participants losing up to 22.5% of their total body weight. In contrast, semaglutide typically yields an average weight loss of 12–15%, depending on the dosage and how long it’s used. However, results can vary significantly between individuals—some patients may respond more effectively to one medication over the other, depending on factors like metabolism, medical history, and lifestyle.
Both tirzepatide and semaglutide are administered as once-weekly injections, with doses that are typically titrated up gradually to improve tolerance and reduce side effects.
When it comes to pricing and access, tirzepatide (sold as Mounjaro or Zepbound) tends to be more expensive, with fewer compounded options compared to semaglutide. However, it is available through trusted telehealth providers, many of which offer direct access to licensed compounding pharmacies. Semaglutide, by contrast, is more widely available and often more affordable, especially when sourced from reputable telehealth platforms that specialize in GLP-1 therapy.
Trying to decide between tirzepatide and semaglutide? The best choice depends on your weight loss goals, sensitivity, and budget. Here’s a quick breakdown:
Looking for GLP-1 options that fit your lifestyle and budget? Click here to compare top providers.
When your appetite drops on GLP-1s, it’s easy to overlook what your body still needs. Even small meals and snacks can fall short on key nutrients. Learn which five essentials are most commonly missed—and how to make sure you’re getting enough to stay energized and healthy.
The Ozempic shortage is officially over—but that doesn’t mean compounded GLP-1s are going away. In this article, we explore why many patients still choose compounded semaglutide for affordability, flexibility, and convenience—even as brand-name options return to shelves.
Skip the waiting room—getting a prescription for GLP-1 medications like semaglutide or tirzepatide is easier than ever thanks to telehealth. In this guide, we break down how you can qualify, consult with a licensed provider, and receive your medication directly at home—all without stepping foot in a clinic.
